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Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT1A receptors modulating serotonin and dopamine synthesis in rat brain in vivo

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jun 2002Publisher:Elsevier BVJournal:Neuroscience Letters, volume 326, pages 121-124 (issn: 0304-3940,

Authors: Jesús A. García-Sevilla; Jesús A. García-Sevilla; Antonio Miralles; Antoni Sastre-Coll; Susana Esteban; David Moranta;

doi: 10.1016/s0304-3940(02)00313-0

pmid: 12057843

Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT1A receptors modulating serotonin and dopamine synthesis in rat brain in vivo

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Abstract

The in vivo sensitivity of presynaptic 5-HT(1A) receptors (autoreceptors and heteroreceptors) modulating the synthesis of 5-hydroxytryptophan/serotonin (5-HTP/5-HT) and 3,4-dihydroxyphenylalanine/dopamine (DOPA/DA) in rat brain was investigated after ethanol treatment and withdrawal. In saline-treated rats as well as in acute ethanol (2 g/kg, intraperitoneally (i.p.), 2 h)- and chronic ethanol (2 g/kg for 7 days)-treated rats, a low dose of the 5-HT(1A) receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT; 0.1 mg/kg, i.p., 1 h) did not decrease the synthesis of 5-HTP in brain (except modestly in striatum; 20% after the chronic treatment) or that of DOPA in striatum. In contrast, in chronic ethanol-withdrawn rats (24 h), 8-OH-DPAT significantly decreased the synthesis of 5-HTP in the hippocampus (29%), cerebral cortex (41%) and striatum (33%) and that of DOPA in the striatum (28%). Similar effects were induced by the mixed 5-HT(1A) agonist/D(2) antagonist buspirone (1 mg/kg, i.p., 1 h) which also decreased 5-HTP synthesis in the hippocampus (24%), cerebral cortex (36%) and striatum (35%) of chronic ethanol-withdrawn rats. These results indicate that chronic ethanol and more clearly the spontaneous withdrawal from chronic ethanol induce supersensitivity of 5-HT(1A)-auto/heteroreceptors modulating the synthesis of 5-HT and DA in rat brain.

Related Organizations

Spanish National Research Council
Spain
University of Geneva
Switzerland
University of the Balearic Islands
Spain

Keywords

Cerebral Cortex, Male, 8-Hydroxy-2-(di-n-propylamino)tetralin, Serotonin, Ethanol, Dopamine, Presynaptic Terminals, Brain, Hippocampus, Buspirone, Corpus Striatum, Dihydroxyphenylalanine, Rats, Serotonin Receptor Agonists, 5-Hydroxytryptophan, Rats, Sprague-Dawley, Receptors, Serotonin, Chronic Disease, Animals, Receptors, Serotonin, 5-HT1

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