Natural gas hydrate(NGH) is a clean resource with huge reserves. The depressurization method is an economical and effective exploitation method. In the process of depressurization, reservoir absolute permeability has an important influence on production results. Based on the data of Shenhu hydrate reservoirs, this paper established a depressurization production numerical simulation model. Then, the production performances such as pressure, temperature, gas production rate, cumulative gas production, and hydrate dissociation effect are all studied under different permeability conditions.study the change of reservoir pressure, gas production rate, cumulative gas production, reservoir temperature change and hydrate dissociation effect under different permeability conditions. Results show that higher permeability is conducive to the depressurization of hydrate reservoirs.