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Treatment of Alcohol Withdrawal Syndrome with Gabapentin

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 May 1999Publisher:Georg Thieme Verlag KGJournal:Pharmacopsychiatry, volume 32, pages 107-109 (issn: 0176-3679, eissn: 1439-0795,

Authors: Bonnet, Udo; Banger, Markus; Leweke, F.M.; Maschke, Matthias; Kowalski, Thorsten; Gastpar, M.;

doi: 10.1055/s-2007-979203

pmid: 10463378

Treatment of Alcohol Withdrawal Syndrome with Gabapentin

- Summary
- Subjects
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Abstract

Four in-patients with moderate alcohol-withdrawal syndromes benefited from treatment with gabapentin administered in an add-on fashion to clomethiazole. In comparison with the amount of clomethiazole required as estimated using a specially developed score during previous detoxifications of these patients at our hospital, gabapentin (400 mg q.i.d.) clearly reduced the amount of clomethiazole needed now Gabapentin, an anticonvulsant with favorable pharmacokinetic properties and tolerability, and with no known risk of dependence, may therefore be a useful new drug in the treatment of alcohol withdrawal. We believe that the potential value of gabapentin in alcohol withdrawal deserves further controlled studies.

Related Organizations

Heinrich Heine University Düsseldorf
Germany
University of Bonn
Germany
University of Duisburg-Essen
Germany

Keywords

Adult, Male, Cyclohexanecarboxylic Acids, Medizin, Acetates, Drug Administration Schedule, Humans, Amines, gamma-Aminobutyric Acid, Ethanol, Central Nervous System Depressants, Middle Aged, Substance Withdrawal Syndrome, Treatment Outcome, Anticonvulsants, Drug Therapy, Combination, Female, Gabapentin, Chlormethiazole

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	89
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%