<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Detection of vulnerable neurons damaged by environmental insults in utero

descriptionPublicationkeyboard_double_arrow_right Article , Journal 25 Jan 2017Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 114, pages 2,367-2,372 (issn: 0027-8424, eissn: 1091-6490,

Authors: Masaaki Torii; Masanori Sasaki; Yu-Wen Chang; Seiji Ishii; Stephen G. Waxman; Jeffery D. Kocsis; Pasko Rakic; +1 Authors

doi: 10.1073/pnas.1620641114

pmid: 28123061

pmc: PMC5338500

Detection of vulnerable neurons damaged by environmental insults in utero

- Summary
- Subjects
- Metrics

Abstract

Significance We have developed a fluorescence reporter system in mice capable of exposing neurons that survive prenatal damage but remain vulnerable in postnatal life. This reporter system can be exploited to study molecular and cellular mechanisms involved in neuronal response to stress and pathogenesis of various tissues and organs during development as well as in adulthood.

Related Organizations

George Washington University
United States
Lyon Neuroscience Research Center
France
VA Connecticut Healthcare System
United States
Children’s National Health System
United States
Sapporo Medical University
Japan

View all View all

Keywords

Cerebral Cortex, Neurons, Nicotine, Ethanol, Mice, Transgenic, Embryo, Mammalian, Flow Cytometry, Response Elements, Luminescent Proteins, Mice, Electroporation, Gene Expression Regulation, Heat Shock Transcription Factors, Genes, Reporter, Pregnancy, Prenatal Exposure Delayed Effects, Animals, Female, Heat-Shock Response, Plasmids

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	19
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%