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Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats

descriptionPublicationkeyboard_double_arrow_right Article , Journal 02 Jan 2020Publisher:Informa UK LimitedJournal:Bioscience, Biotechnology, and Biochemistry, volume 84, pages 159-170 (issn: 0916-8451, eissn: 1347-6947,

Authors: Kensuke Yamamura;

Keiichiro Okamoto; Yosuke Nakatani; Shiho Shimizu; Mayumi Taiyoji; Ritsuo Takagi; Makio Saeki; +1 Authors

doi: 10.1080/09168451.2019.1662278

pmid: 31483212

Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats

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Abstract

ABSTRACT We tested whether Sake Lees (SL) had inhibitory effects on hyperalgesia in the hindpaw under psychophysical stress conditions. Male rats were subjected to repeated forced swim stress treatments (FST) from Day −3 to Day −1. Intraperiotoneal administration of SL which contained low concentration of ethanol (SLX) was conducted after each FST. On Day 0, formalin-evoked licking behaviors and Fos responses in the lumbar spinal cord (DH) and several areas within the rostral ventromedial medulla (RVM) were quantified as nociceptive responses. FST-induced hyperalgesia in the hindpaw was prevented by repeated SL and SLX treatments. Fos expression was significantly increased in DH and some areas within the RVM under FST, which was prevented by repeated SL or SLX. These findings indicated that daily administration of SL had the potential to alleviate stress-induced hyperalgesia.

Related Organizations

Saint-Hyacinthe Research and Development Centre
Canada
Niigata Agricultural Research Institute
Japan
Niigata University
Japan
Saint-Hyacinthe Research and Development Centre
Canada
Niigata University
Japan

Keywords

Male, Serotonin, Spinal Cord Dorsal Horn, Rats, Sprague-Dawley, Stress, Physiological, Formaldehyde, Animals, Pain Management, Pain Measurement, Behavior, Animal, Ethanol, Plant Extracts, Oryza, Immunohistochemistry, Hindlimb, Rats, Hyperalgesia, Fermentation, Proto-Oncogene Proteins c-fos, Serotonergic Neurons

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