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Antioxidant and antiproliferative activity ofStachys glutinosaL. ethanol extract

descriptionPublicationkeyboard_double_arrow_right Article , Journal 10 Sep 2014 Italy Publisher:Informa UK LimitedJournal:Natural Product Research, volume 29, pages 899-907 (issn: 1478-6419, eissn: 1478-6427,

Authors: LEPORINI, LIDIA; MENGHINI, LUIGI; Foddai, Marzia; Petretto, Giacomo Luigi; Chessa, Mario; Tirillini, Bruno; Pintore, Giorgio;

doi: 10.1080/14786419.2014.955490

pmid: 25205114

handle: 11564/645371 , 11388/61139 , 11576/2642522

Antioxidant and antiproliferative activity ofStachys glutinosaL. ethanol extract

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Abstract

Ethanol extracts of Stachys glutinosa L. (Lamiaceae) were investigated for antioxidative properties, as well as antiproliferative action on various cell lines. The antioxidant activities were investigated by ABTS (2,2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid) assay, DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging, β-carotene/linoleic acid assay, scavenging of hydrogen peroxide (horseradish peroxidase test), superoxide anion scavenging, and hypochlorous acid scavenging (taurine test). The antioxidant activity was reported as IC50 and reveals antioxidant effects. Antiproliferative effects were measured in vitro on three cell lines: HepG2 (human hepatocarcinoma), MCF7 (breast human adenocarcinoma) and C2C12 (mouse myoblast) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The ethanol extract induced variations in cell viability on all cell lines tested. At 200 μg/mL, the effects on cell viability were - 23%, - 27% and - 37%, respectively, for C2C12, MCF7 and HepG2.

Country

Italy

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Keywords

Ethanol, Cell Survival, Plant Extracts, Antineoplastic Agents, Phytogenic, Antioxidants, Mass Spectrometry, antioxidant; antiproliferative activity; ethanol extracts; Stachys glutinosa L; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Ethanol; Glycosides; Humans; Inhibitory Concentration 50; Mass Spectrometry; Mice; Phenols; Plant Extracts; Stachys; Plant Science; Biochemistry; Analytical Chemistry; Organic Chemistry; Medicine (all), Inhibitory Concentration 50, Mice, Phenols, Cell Line, Tumor, Stachys glutinosa L; ethanol extracts; antioxidant, antiproliferative activity, Animals, Humans, Stachys, Stachys glutinosa L; antioxidant; antiproliferative activity; ethanol extracts; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Ethanol; Glycosides; Humans; Inhibitory Concentration 50; Mass Spectrometry; Mice; Phenols; Plant Extracts; Stachys, Glycosides, Chromatography, High Pressure Liquid

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