AbstractMany Mediterranean coastal areas encounter similar problems and gaps between science, governance, and implementation of sustainable management at local-regional scales. There is often a lack of coordination between management of inland and coastal areas, and a lack of integrated land-sea data and knowledge exchange to support transitions towards sustainable development and synergies between rural and coastal areas. In this paper, we illustrate the main challenges to reach a sustainable development of coastal-rural areas related to data availability, knowledge exchange and governance, which could be tackled by coupling regional and international research infrastructures (RIs) with scientific and stakeholder collaboration networks to facilitate knowledge exchange and co-creation of solutions. We first identified the main challenges in sustainable development of coastal-rural areas followed by a review of major existing RIs, scientific knowledge and collaboration networks that can help support integrated management of Mediterranean coastal zones. Based on this, we developed recommendations for a better integration of RIs and collaboration networks in the management of coastal-rural areas, including (1) the creation of local networks to facilitate periodical meetings between all sectors involved and to connect science and policy actors and (2) setting up local RIs that support the data processing and the use of regional and international RIs by scientists and policy stakeholders.