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Immunohistochemical Demonstration of Ethanol-Inducible

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1993Publisher:Oxford University Press (OUP)Journal:Alcohol and Alcoholism, volume 28, pages 69-75 (issn: 0735-0414, eissn: 1464-3502, Copyright policy )
Authors: Makoto Okumura; Seiichiro Kamimura; Masanori Shimizu; Tetsuro Sohda;

doi: 10.1093/alcalc/28.supplement_1b.69

pmid: 8003132

Immunohistochemical Demonstration of Ethanol-Inducible

Abstract

The microsomal ethanol-oxidizing system (MEOS) is a P450-dependent pathway for ethanol oxidation in hepatic microsomes. The bulk of MEOS activity is catalyzed by P450 2E1 (an ethanol-inducible isozyme of P450) in animal livers treated with ethanol. Rat brains also metabolize certain drugs, and it is theorized that a mechanism for drug metabolism exists within the brain which acts on P450. We compared immunohistochemical localization of P450 2E1 between ethanol-treated rats and pair-fed control rats. In control rats, immunoreactive P450 2E1 was detected in minute amounts in both basal ganglia and cerebellar cortices. After ethanol treatment, the content of P450 2E1 increased in the basal ganglia, and the enzyme was also induced in the cerebellar cortices, substantia nigra and hippocampus. We speculate that the rat brain metabolizes ethanol by P450 2E1.

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Keywords

Male, Neurons, Ethanol, Brain, Cytochrome P-450 CYP2E1, Oxidoreductases, N-Demethylating, Rats, Immunoenzyme Techniques, Rats, Sprague-Dawley, Alcoholism, Cytochrome P-450 Enzyme System, Enzyme Induction, Animals

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Average
Top 10%
Top 10%
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