AbstractA Pandemic devastates the life of global citizens and causes significant economic, social, and political disruption. Evidence suggests that Pandemic’s likelihood has increased over the past century because of increased global travel and integration, urbanization, and changes in land use. Further, evidence concerning the urban character of the Pandemic has underlined the role of cities in disease transmission. An early assessment of the severity of infection and transmissibility can help quantify the Pandemic potential and prioritize surveillance to control of urban areas in Pandemics. In this paper, an Urban Vulnerability Assessment (UVA) methodology is proposed. UVA investigates the possible vulnerable factors related to Pandemics to assess the vulnerability in urban areas. A vulnerability index is constructed by the aggregation of multiple vulnerability factors computed on each urban area (i.e., urban density, poverty index, informal labor, transmission routes). UVA provides insights into early vulnerability assessment using publicly available data. The applicability of UVA is shown by the identification of high-vulnerable areas where surveillance should be prioritized in the COVID-19 Pandemic in Bogotá, Colombia.