Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice
Copyright policy )Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice
The non-selective opioid receptor antagonist, naltrexone (NAL), reduces alcohol (ethanol) consumption in animals and humans and is an approved medication for treating alcohol abuse disorders. Proopiomelanocortin (POMC)-derived melanocortin (MC) and opioid peptides are produced in the same neurons in the brain, and recent pre-clinical evidence shows that MC receptor (MCR) agonists reduce excessive ethanol drinking in animal models. Interestingly, there is a growing body of literature revealing interactions between the MC and opioid systems in the modulation of pain, drug tolerance, and food intake.
- University of North Carolina at Chapel Hill United States
- University of Chile Chile
- University of Almería Spain
- Universidad Autónoma de Chile Chile
- University of Almería Spain
Binge-Like Drinking, Male, Dose-Response Relationship, Drug, Ethanol, Narcotic Antagonists, Receptors, Melanocortin, MTII, Drug Synergism, Opioid, Peptides, Cyclic, Naltrexone, Binge Drinking, Mice, Inbred C57BL, Synergistic, Mice, alpha-MSH, Melanocortin, Animals, Drug Therapy, Combination
Binge-Like Drinking, Male, Dose-Response Relationship, Drug, Ethanol, Narcotic Antagonists, Receptors, Melanocortin, MTII, Drug Synergism, Opioid, Peptides, Cyclic, Naltrexone, Binge Drinking, Mice, Inbred C57BL, Synergistic, Mice, alpha-MSH, Melanocortin, Animals, Drug Therapy, Combination
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