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Porcine Granulocyte Functions: Evaluation and Modulation

pmid: 2382519
Porcine Granulocyte Functions: Evaluation and Modulation
SummaryFunctions of porcine polymorphonuclear neutrophils are evaluated with in vitro test systems. Results are compared with those from human PMN and the relevance for in vivo conditions is discussed. Ethanol was inhibitory to all porcine PMN functions investigated here. Influex, a combination product, containing extracts of Echinacea, Aconitum, Apis and Lachesis stimulated adherence, chemotaxis, and phagocytosis, but inhibited chemiluminescence. These results suggest an effect of the product in the generation of reactive oxygen species.ZusammenfassungGranulozytenfunktionen beim Schwein: Messung und BeeinflussungVerschiedene Funktionen neutrophiler Granulozyten des Schweines werden mit Hilfe von in vitro‐Systemen gemessen und die Ergebnisse mit entsprechenden Werten verglichen, die für menschliche Neutrophile beschrieben sind. Die Aussagekraft der erhaltenen Ergebnisse für in vivo‐Verhältnisse wird diskutiert. Alle hier beschriebenen Granulozytenfunktionen wurden durch Alkohol gehemmt. Influex, ein Kombinationspräparat, das Extrakte aus Echinacea, Aconitum, Apis und Lachesis enthält, stimulierte Adhärenz, Chemotaxis und Phagozytose, hemmte jedoch die Chemolumineszenz. Die Ergebnisse lassen einen Einfluß des Präparates auf die Bildung von reaktiven Sauerstoffspezies vermuten.
Ethanol, Neutrophils, Swine, Chemotaxis, Leukocyte, Phagocytosis, Cell Adhesion, Animals
Ethanol, Neutrophils, Swine, Chemotaxis, Leukocyte, Phagocytosis, Cell Adhesion, Animals
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