SummaryBackgroundSuccessful management of acne involves choosing proper medication. Chemical peeling is a well‐known option in treatment of acne vulgaris.ObjectiveTo evaluate and compare the clinical efficacy and safety of combination chemical peels vs single peel in treatment of mild‐to‐moderate acne.MethodsThe study included 45 patients with mild‐to‐moderate acne divided into three equal groups. Group A underwent combination sequential peels with modified Jessner's solution (MJ) followed by trichloro acetic acid (TCA20%) on the right (Rt) side of the face vs TCA 30% on the left (Lt) side. Group B was treated by combination peels of salicylic (20%) mandelic (10%) (SM) mixture on the Rt half vs salicylic acid 30% on the Lt half. Group C underwent combination sequential peeling of MJ and TCA on the Rt side vs SM combination peels on the Lt side. All patients received six sessions with 2‐week intervals and followed up for 3 months after the last session. Side effects were reported.ResultsBoth sides of the face showed significant improvement of acne lesions but improvement was significantly higher and earlier in sides treated by combination peels. Side effects were minimal.ConclusionIn conclusion, combination peels achieved a higher and earlier therapeutic response with a reasonable cost that is maintained for a relatively long periods than single peel. Combination sequential peels gave the best results.