Previous research has highlighted how ideological factors such as political self-identification, religiosity and conspiracy thinking influence our beliefs about scientific issues such as climate change and vaccination. Across three studies (combined N = 9,022) we expand on this line of inquiry to show for the first time that the ideological attitudes relating to authoritarianism and group-based dominance predict disagreement with the scientific consensus in several scientific domains. We show these effects are almost entirely mediated by varying combinations of ideological (political ideology, religiosity, free-market endorsement, conspiracy thinking) and science-specific (scientific knowledge, trust in scientists) constructs, depending on the scientific issue in question. Importantly, a general distrust of science and scientists emerges as the most consistent mediator across different scientific domains. We find that, consistent with previous research, the ideological roots of rejection of science vary across scientific issues. However, we also show that these roots may share a common origin in ideological attitudes regarding authority and equality.