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Interactions between Alcohol and the HIV Entry Inhibitor Maraviroc

Name: Interactions between Alcohol and the HIV Entry Inhibitor Maraviroc
Keywords: Adult, Male, maraviroc, Alcohol Drinking, Biological Psychology, Clinical Trials and Supportive Activities, 610, HIV Infections, Maraviroc, Alcohol Use and Health

descriptionPublicationkeyboard_double_arrow_right Article , Journal 23 Jul 2013 United States Publisher:SAGE PublicationsJournal:Journal of the International Association of Providers of AIDS Care (JIAPAC), volume 12, pages 375-377 (issn: 2325-9582, eissn: 2325-9582,

Authors: Gruber, Valerie A; Rainey, Petrie M; Lum, Paula J; Beatty, George W; Aweeka, Francesca T; McCance-Katz, Elinore F;

doi: 10.1177/2325957413495567

pmid: 23881910

pmc: PMC4100473

Interactions between Alcohol and the HIV Entry Inhibitor Maraviroc

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Abstract

Background: Alcohol use is common among people with HIV, and beliefs about alcohol interactions with medications predict decreased medication adherence, risking drug-resistant mutations. Maraviroc is an HIV entry inhibitor approved for treatment of both drug-sensitive and drug-resistant HIV strains. The present study evaluated the effects of alcohol on maraviroc pharmacokinetics and the effects of maraviroc on alcohol pharmacokinetics. Methods: Ten healthy adults completed alcohol (1 g/kg) and placebo alcohol pharmacokinetics sessions before and after 7 days of maraviroc administration. Results: Alcohol concentrations increased 12% following maraviroc. Maraviroc pharmacokinetics were unaffected by alcohol. Conclusions: Maraviroc treatment should not be interrupted if alcohol is consumed.

Country

United States

Related Organizations

University of California, San Francisco
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University of Mary
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University of California System
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Washington State University
United States

Keywords

Adult, Male, maraviroc, Alcohol Drinking, Biological Psychology, Clinical Trials and Supportive Activities, 610, HIV Infections, Maraviroc, Alcohol Use and Health, Substance Misuse, Double-Blind Method, Clinical Research, Cyclohexanes, HIV Fusion Inhibitors, Psychology, Humans, Drug Interactions, Biomedical and Clinical Sciences, Ethanol, alcohol, Evaluation of treatments and therapeutic interventions, Pharmacology and Pharmaceutical Sciences, drug interactions, Triazoles, Alcoholism, Infectious Diseases, Good Health and Well Being, Medical Microbiology, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Area Under Curve, Sexually Transmitted Infections, HIV/AIDS, Women's Health, Female, Antimicrobial Resistance, Infection

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