Land, energy and water are the foundational resources of a country, and have a number of complex interactions with a changing climate. Their exploitation can have significant impacts on climate change, which in turn can affect the future availability of these resources. Thus it is important to properly manage these resources, to ensure that they can continue to provide long into the future. This thesis aims to assess the climate, land-use, energy and water systems (CLEWs) nexus in Bolivia, to determine critical points of interactions, and to produce recommendations for policy actions. This includes both mitigation and adaptation actions. The results show that Bolivia’s projected demand increases are certainly manageable, and with the investments as outlined, they can easily be satisfied, while reducing emissions and increasing climate resilience. An important result is that municipal and thermal water demand don’t appear to be limiting constraints, and so water management efforts should focus on agricultural and hydropower use. Recommended future work is to increase the scope and detail of the water and land model, so that all of the planned hydropower projects are included, and so that agriculture and irrigation demands and impacts can be more accurately predicted.