Abstract Climate change (CC) is likely to have a long-term influence on regional water resources, including surface water and groundwater. Therefore, quantifying the CC influence is indispensable for proper management of water resources. This study scrutinized the influence of CC on river discharge and groundwater recharge (GWR) in Ho Chi Minh City (HCMC), Vietnam, utilizing the Soil and Water Assessment Tool (SWAT). The calibrated SWAT was utilized to simulate the discharge and GWR under projected climate scenarios in reliance on an ensemble of seven General Circulation Models (GCMs) derived from Coupled Model Intercomparison Project Phase 6 (CMIP6) under three Shared Socioeconomic Pathways (SSPs), including SSP1-2.6, SSP2-4.5, and SSP5-8.5. Results pointed out that the climate of HCMC is warmer and wetter in the 21st century. Under the CC influence, the future discharge is envisaged to rise from 0.1 to 4.5% during the near-future period of 2030s (2021–2045), 8.1 to 11.6% during the mid-future period of 2055s (2046–2070), and 7.7 to 19.6% during the far-future period of 2080s (2071–2095) under the three SSP scenarios. In addition, the GWR is prognosticated to have rising trends of 0.9–4.9%, 5.3–7.9%, and 5.7– 13.5% during the near-future, mid-future, and far-future periods, respectively. Furthermore, uncertainties in the discharge and GWR projections connected with SSP scenarios and CMIP6 GCMs are considerable.