Отмечена роль ведущих отечественных ученых В.И. Денисова и В.Г. Горского в становлении и развитии теории планирования эксперимента и прикладных статистических методов анализа данных. На основе математической теории планирования эксперимента исследовано влияние параметров воздушной среды рабочих помещений на интенсивность испарения опасных химических веществ с поверхности пролива. Создана математическая модель, описывающая этот процесс. Данные исследования необходимы для оценки профессионального риска на химических производствах The article addresses the important problem of assessing the professional risk of workers in industries where the chemical factor is possible, as well as the role of the mathematical theory of experimental design in conducting of experimental research. The role of leading Russian scientists Denisov Vladimir Ivanovich and Gorsky Vladimir Grigoryevich in the establishment and development of experimental design theory and applied statistical data analysis methods is noted in the work. It is noted that in order to successfully solve scientific, industrial, and technological problems, modern research engineer must have competencies in the field of the theory of mathematical statistics, practical skills in planning an experiment, and methods for statistical processing of experimental data. The aim of the studies presented in this paper is to assess the influence of the air environment of the working room (temperature, humidity) on the rate of evaporation of a hazardous chemical from the spill. The experiment was carried out on a facility that allowed varying over a wide range the temperature and humidity. The experiment was carried out in accordance with the plan developed on the basis of the mathematical theory of experimental design. The obtained mathematical model allows estimating the level of air pollution by hazardous chemicals in the temperature and humidity range typical of workrooms. A comparison of the concentrations calculated according to the model with the permissible level of air pollution (MPC of the working zone air) will allow assessing the risk of inhalation exposure to hazardous chemicals on working personnel in local emergency situations. Conducted research is necessary to assess occupational risk in chemical industries