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The Effect of Cimetidine on Ethanol Concentrations in Fasting Women and Men after Two Different Doses of Alcohol

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1997Publisher:Informa UK LimitedJournal:Scandinavian Journal of Gastroenterology, volume 32, pages 217-220 (issn: 0036-5521, eissn: 1502-7708,

Authors: P. Ott; L. Sestoft; J. O. Clemmesen;

doi: 10.3109/00365529709000197

pmid: 9085457

The Effect of Cimetidine on Ethanol Concentrations in Fasting Women and Men after Two Different Doses of Alcohol

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Abstract

Serum ethanol concentrations may become higher when alcohol is consumed during treatment with histamine receptor antagonists, especially if ethanol is ingested postprandially. Only a few studies have investigated fasting subjects, and women have only been investigated sporadically.The present study compared serum ethanol concentrations after a 4-h fast followed by a low (0.15 g/kg) and a high (0.45 g/kg) dose of ethanol, on two separate occasions in six women and six men. The study was carried out before and after treatment with 400 mg cimetidine twice daily.Cimetidine administration did not change the area under the concentration-time curve or the maximal serum ethanol concentration in either women or men, irrespective of ethanol dose. Ethanol elimination rate was unchanged by cimetidine.Cimetidine does not influence the ethanol concentration-time curve when ethanol is ingested on an empty stomach.

Related Organizations

Gentofte Hospital
Denmark
Gentofte Hospital
Denmark

Keywords

Adult, Male, Ethanol, Fasting, Histamine H2 Antagonists, Area Under Curve, Humans, Female, Cimetidine

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