Salinity impedes soil and crop productivity in over 900 million ha of arable lands worldwide due to the excessive accumulation of salt (NaCl). To utilize saline soils in agriculture, halophytes (salt-tolerant plants) are commonly cultivated. However, most food crops are glycophytes (salt-sensitive). Thus, to enhance the productivity of saline soils, gypsum (CaSO4·2H2O) as well as bio-organic (combined use of organic materials, such as compost and straw with the inoculation of beneficial microbes) amendments have been continuously recognized to improve the biological, physical and chemical properties of saline soils. CaSO4·2H2O regulates the exchange of sodium (Na+) for calcium (Ca2+) on the clay surfaces, thereby increasing the Ca2+/Na+ ratio in the soil solution. Intracellularly, Ca2+ also promotes a higher K+/Na+ ratio. Simultaneously, gypsum furnishes crops with sulfur (S) for enhanced growth and yield through the increased production of phytohormones, amino acids, glutathione and osmoprotectants, which are vital elicitors in plants’ responses to salinity stress. Likewise, bio-organic amendments improve the organic matter and carbon content, nutrient cycling, porosity, water holding capacity, soil enzyme activities and biodiversity in saline soils. Overall, the integrated application of gypsum and bio-organic amendments in cultivating glycophytes and halophytes is a highly promising strategy in enhancing the productivity of saline soils.