The growth of energy consumption has led to the depletion of fossil energy and the increasing greenhouse effect. In this case, low carbonization has become an important trend in the world’s energy development, in which clean energy occupies an important position. The uncertainties brought by the large-scale integration of wind power, photovoltaic and other renewable energy sources into the grid pose a serious challenge to system dispatch. The participation of demand response (DR) resources can flexibly cooperate with renewable energy, optimizing system dispatch and promoting renewable energy consumption. Thus, we propose a flexible DR scheduling strategy based on multiple response modes in this paper. We first present a DR resource operation model based on multivariate response modes. Then, the uncertainties are considered and dealt with by scenario generation and reduction technology. Finally, a day-head dispatch strategy considering flexible DR operation and wind power uncertainties is established. The simulation results show that the proposed strategy promotes wind power consumption and reduces system operation costs.