The present study utilizes three high-resolution simulations from the Regional Climate Model version 4 (RegCM4) to examine the late 21st century changes (2080–2099) in the West African Monsoon (WAM) features. A set of three Earth System Models are utilized to provide initial and lateral boundary conditions to the RegCM4 experiments. Our analysis focuses on seasonal mean changes in WAM large-scale dynamical features, along with their connections with the summer monsoon precipitation. In the historical period, the simulation ensemble means mimic reasonably well the intensity and spatial distribution of the WAM rainfall as well as the WAM circulation patterns at different scales. The future projection of the WAM climate exhibits warming over the whole West Africa leading to precipitation reduction over the Sahel region, and a slight increase over some areas of the Guinea Coast. The position of the African Easterly Jet (AEJ) is shifted southward and the African Easterly Waves (AEWs) activities are reduced, which affect in turn the WAM rainbelt characteristics in terms of position and strength. Overall the changes in simulated AEJ and AEWs contribute substantially to reduce the seasonal summer mean precipitation in West Africa by the late 21st century, with prevailing negative changes in the Savanna-Sahel region. To further explore the robustness of the relationships revealed in this paper, future studies using different high-resolution regional climate models with large ensemble are recommended.