In order to meet consumer demands for electric transportation, the energy density of lithium-ion batteries (LIB) must be improved. Therefore, a trend to increase the overall size of the individual cell and to decrease the share of inactive materials is needed. The process of electrolyte filling involves the injection of electrolyte liquid into the cell, as well as the absorption of the electrolyte into the pores of the electrodes and the separator, which is known as wetting. The trend towards larger-format LIB challenges the electrolyte filling due to an increase in wetting distance for the electrolyte as well as a decrease in the void volume of the cell. The optimization of the process via numerical simulation promises to reduce costs and ensure quality during battery production. The two models developed in this study are based on a commercial computational fluid dynamics (CFD) program to study the effect of process parameters, such as pressure and temperature, on the filling process. The results were verified with neutron radiography images of the dosing process and a feasibility study for a wetting simulation is shown. For all simulations, specific recommendations are provided to set up the electrolyte filling process, based on which factors generate the greatest improvement.