The concept of sustainability introduced in 1987 has characterised the world of research in the AEC (Architecture, Engineering, and Construction) sector, directing it to try to tackle the problems inherent to the impacts of climate change on buildings. In addition, the advent of COVID-19, disrupting the world and people’s habits, has obviously also strongly affected the academic world. Indeed, this paper aims to analyse the changes and differences between the pre- and post-pandemic periods through a two-stage hybrid literature review. First, through a systematic literature review, 90 articles were selected, filtered through different keywords (sustainability, climate, architecture, and buildings). Once the reasoned selection of papers had been made, it was possible to proceed to the second phase, which involved a thematic analysis according to the three classic macro themes of sustainability (Environment, Social, and Economic) and the inclusion of a fourth macro theme (Management and Development), which made it possible to reintroduce a holistic view of the problem. The results of this literature review revealed the presence of a growing interest in the topic analysed and a more homogenous distribution across all continents, with no distinction between developed and developing countries. Economic sustainability interests emerge post-COVID-19 through the deepening of the themes of clean energy and direct control of consumption. At the level of Environmental sustainability, on the other hand, COVID-19 replaced the house at the centre of people’s lives. In addition, the Management and Development macro theme highlighted the need for an integrated view of the problem and the unexpected return of researchers preferring new constructions, which, despite alternative green approaches and renovations, can guarantee better performance.