The objective of this study is to perform trend analysis in the historic data sets of annual and crop season [May–September] precipitation and daily maximum and minimum temperatures across the southwest United States. Eighteen ground-based weather stations were considered across the southwest United States for a total period from 1902 to 2017. The non-parametric Mann–Kendall test method was used for the significance of the trend analysis and the Sen’s slope estimator was used to derive the long-term average rates of change in the parameters. The results showed a decreasing trend in annual precipitation at 44.4% of the stations with the Sen’s slopes varying from −1.35 to −0.02 mm/year while the other stations showed an increasing trend. Crop season total precipitation showed non-significant variation at most of the stations except two stations in Arizona. Seventy-five percent of the stations showed increasing trend in annual maximum temperature at the rates that varied from 0.6 to 3.1 °C per century. Air cooling varied from 0.2 to 1.0 °C per century with dominant warming phenomenon at the regional scale of the southwest United States. Average annual minimum temperature had increased at 69% of the stations at the rates that varied from 0.1 to 8 °C over the last century, while the annual temperature amplitude showed a decreasing trend at 63% of stations. Crop season maximum temperature had significant increasing trend at 68.8% of the stations at the rates varying from 0.7 to 3.5 °C per century, while the season minimum temperature had increased at 75% of the stations.