Dilation behavior is of great importance for reasonable modeling of the stability of the host rock of the repository for high-level radioactive waste disposal. It is a suitable method for carrying out direct shear experiments to analyze the dilation behavior of rock with well understood physical meanings. Based on a series of direct shear experiments on granite samples from the Alxa candidate area under different normal stresses, the shear stress‒shear strain and shear stress‒normal strain relations have been studied in detail. Five typical stages have been divided associated with the fracturing process and deformation behaviors of the granite samples during the experimental process, and the method to determine the typical stress thresholds has been proposed. It has also been found that the increasing normal stress may reduce the maximum dilation angle, and when the normal stress is relatively lower, the negative dilation angle may occur during the post-peak stage. According to the data collected from the direct shear tests, an empirical model of the mobilized dilation angle dependent on normal stress and plastic shear strain is proposed. This mobilized dilation angle has clear physical meanings and can be used in plastic constitutive models of the host rock of the repository, and this analysis can also be put forward to other types of geomechanical problems, including the deformation behaviors related to landslide, earthquake, and so on.