Motivated by the environmental challenges and the increase in energy demand, this review assesses the suitability of nuclear power production as an alternative option to using fossil fuels. First, we assess the competitiveness of nuclear power compared to other power sources considering its economic efficiency, environmental impact and implications for health, and conclude that this is a viable option to serve in addition to and as a backup to renewable sources. Second, we review previous findings in various fields on advantages and disadvantages of nuclear power technology and conclude that there is a gap between reality and perception. Third, we discuss challenges related to nuclear weapons proliferation and misperceived public opinion on nuclear power. We conclude that the gap between perception and reality stems from a lack of consolidated interdisciplinary view, media communications focusing mainly on unilateral assessments.