The performance of photovoltaic panels decreases depending on the different factors to which they are subjected daily. One of the phenomena that most affects their energy production is dust deposition. This is particularly acute in desert climates, where the level of solar radiation is extreme. In this work, the effect of dust soiling is examined on the electricity generation of an experimental photovoltaic pilot plant, installed at the Solar Energy Research Center (CIESOL) at the University of Almería. An average reduction of 5% of the power of a photovoltaic plant due to dust contamination has been obtained, this data being used to simulate the economic effect in plants of 9 kWp and 1 and 50 MWp. The economic losses have been calculated, and are capable of being higher than 150,000 €/year in industrial plants of 50 MWp. A cleaning strategy has also been presented, which represents a substantial economic outlay over the years of plant operation.