Attaining a good level of internal comfort is possible by controlling various parameters. Among all, the thermo-hygrometric comfort and the indoor air quality are of fundamental importance. This research is developed with the aim of verifying the indoor air quality following the installation of a passive cooling device in a historic building located in the province of L’Aquila in the municipality of Poggio Picenze in climatic zone E. This research aims to verify the functioning of a ventilation duct installed between the hypogeal and the second level of the structure that was installed to obtain air recirculation by exploiting the inertial potential of the hypogeal room. The first phase of the research was aimed at thermo-hygrometric monitoring using sensors installed on-site and controlled remotely in order to verify the operation of the device. The second-phase object of this text was useful in investigating the acquired indoor air quality level.