The current exploration aims to inspect the features of thermal radiation on the buoyancy or mixed convective fluid flow induced by nanofluid through a stretching permeable bended sheet. The impact of activation energy and binary reaction along with slip migration is taken into account to discuss the fine points of water-based alumina nanoparticle flow. The structure of the curved sheet is assumed to be stretchable and the bended texture is coiled within a circular section with radius Rb. The similarity technique is utilized to reduce the leading partial differential equations into ordinary differential equations. These reduced equations are then deciphered numerically by employing the bvp4c method. The outcomes of the model were constructed in the form of several figures and bar graphs for the case of opposing and assisting flows with varying distinct embedded control parameters. The results display that the velocity field curves escalate with a higher radius of curvature parameter while temperature and concentration profiles shrink. More precisely, the outcomes show that the temperature distribution profile increases with the increase in nanoparticle’s volume fraction as well as thermal radiation parameter. Meanwhile, the concentration and velocity fields are decelerated with higher impacts of nanoparticle volume fraction. In addition, the heat and mass transfer rates were significantly improved for the higher value of the radiation and Schmidt number. On the other hand, the growing values of the velocity slip factor decrease the shear stress. Furthermore, the results are compared with the previous results in the limiting cases and observed a tremendous harmony.