With the background of implementing carbon peaking and carbon neutralization, identifying methods to realize energy-saving and carbon reduction effectively has become an important issue in the intelligent energy-conservation manufacturing industry. During the process of achieving this goal, determining an optimal location for a low-carbon and intelligent manufacturing industrial park is a foremost decision-making problem for manufacturing corporations’ energy-efficient development. The article established a multi-criteria decision framework to assist manufacturing companies when selecting suitable industrial park sites. To begin with, an evaluation criteria framework is confirmed by literature search. Then, a fuzzy optimization model, which combines the fuzzy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and the fuzzy VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) is presented, where fuzzy TOPSIS is used to determine the decision-maker criteria weights. Then, criteria weights are calculated by the optimization model with construction of a Lagrange function. Moreover, the fuzzy VIKOR method is applied to sort alternatives and choose the best alternative location. In addition, five alternative sites for a manufacturing company are evaluated and ranked according to the values of the ranking index as a numerical case to demonstrate the proposed framework’s application. Finally, a comprehensive analysis of diverse methods and sensitivity analyses for the volatility in criteria weights and decision-maker weights is illustrated to confirm that the framework is practicable for the problem of intelligent and sustainable manufacturing industrial park-site selection.