Hydrogen is a key enabler of a sustainable society. Refurbishment of the existing natural gas infrastructure for up to 100% H2 is considered one of the most energy- and resource-efficient energy transportation methods. The question remains whether the transportation of 100% H2 with reasonable adaptions of the infrastructure and comparable energy amounts to natural gas is possible. The well-known critical components for refurbishment, such as increased compressor power, reduced linepack as well as pipeline transport efficiencies, and their influencing factors were considered based on thermodynamic calculations with a step-by-step overview. A H2 content of 20–30% results in comparable operation parameters to pure natural gas. In addition to transport in pipelines, decentralized H2 production will also play an important role in addressing future demands.