Scots pine is an adaptable and prevalent European tree species that grows naturally throughout Europe and has been planted in a wide range of environments. Previous studies have indicated that climatic variables affect tree-ring growth patterns in this species, but it is also possible that certain aspects of the growth environment moderate this response. In order to understand the potential impact a shifting climate has on this important species, this study compared the growth response of two populations of Scots pine. Trees from similar bioclimatic regions in Hungary and Poland were compared using the hypothesis that differences in the association between climate and growth would be reflected by the degree of tree-ring width variation. We also wanted to know how changing climatic conditions influenced the temporal stability of the climate–growth signal in the most important periods for tree growth. Clear similarities in the effect of temperature and precipitation on tree-ring width variation were found between the two sites, but there were also some interesting differences. In the late winter to early spring period both populations reacted to warming with a decreasing association with temperature. Summer precipitation was shown to be the dominant factor in controlling ring-width. A decreasing trend in summer precipitation values at both Hungarian and Polish sites resulted in a weakening in correspondence for the Hungarian trees, while the Polish trees showed a significant increase in correlation with summer precipitation. The results indicated that changes in climate influenced the studied trees in different ways which has implications for the future balance of Scots pine growth in Europe.