Despite being considered renewable, corn (Zea mays) ethanol still generates much debate over the use of fossil fuels in its production and is considered less sustainable than sugarcane (Saccharum spp.) ethanol. In Brazil, corn ethanol is starting to be produced in the Center-West and is expected to increase with the RenovaBio, a promising policy for biofuels adoption. In this context, energy cane (Saccharum spp.) is a biomass crop with high yields that can provide bagasse to supply the energy demand of the corn ethanol industry and provide juice with about 10% sugar content. However, the effects of introducing its juice in the production process are unknown. For these reasons, the objective of this study was to assess the effects of adding energy cane juice in corn ethanol production. Energy cane juice brings several advantages: (i) It provides sugars that can reduce by almost 50% the amount of corn and enzymes used, (ii) reduces the amount of water needed for ethanol production, and (iii) increases significantly the fermentation efficiency from 86.4% to 90.8% by providing minerals that support yeast growth. Therefore, energy cane can be integrated into the corn ethanol production process, making the fermentation more efficient and the production systems more sustainable.