The lifetime of offshore foundations is governed by a combination of harsh environmental conditions and complex service loads. The fatigue limit state (FLS) analysis needs to be performed in the time domain to capture the complex phenomenon. This study aims to investigate different parameters and design modifications that can impact the design life of an offshore jacket foundation. An OC4 jacket foundation is designed in industrial software from DNV and reduced to a super-element model. The super-element model is connected to an NREL 5-MW wind turbine designed in Bladed. The time-series loads are used to compute the fatigue damages faced by the foundation during the service life. The impact of soil non-linearity, marine growth, scour size, the mass of the transition piece, and the grouted connection’s design on the dynamic response and fatigue damages are compared. A 30% increase in life was observed by replacing the concrete transition piece with a lightweight steel configuration. The fatigue damages were considerably greater for the inclined pile in the leg grouted connection than for the leg in the pile concept. The study provides a different perspective by analysing the effect of design parameters and design changes in the complex and computationally expensive time-series domain.