In the last two centuries, land-use change (LUC) has been the most important direct change driver for terrestrial ecosystems. In contrast with the consequent ecosystem degradation, forward-looking spatial policies and target landscape and land-use planning processes are needed from a sustainability perspective. The present paper proposes a framework of action, including different landscape-planning and ecological approaches: from spatial modelling to recognize LUC and build different scenarios, to ecosystem service (ES) assessment to evaluate possible environmental impacts. Three different scenarios were explored: Trend, No Tillage, and Energy crops. The sediment delivery ratio and carbon storage and sequestration ESs were assessed and compared for each scenario. The results show that regional development in line with past trends could lead to further land degradation (with ES value losses, in a decade, greater than 5%). Instead, the two scenarios proposed in compliance with EU policies could bring benefits, if only those related to moderate LUCs and respecting the naturally grass-vegetated land. The aim of the paper is to support decision makers and local communities in the landscape planning landscape planning process. From the local to global scale, guided and shared LUC management allows us to implement sustainable development, based not only on a deep knowledge of the physical environment but also of social and economic issues.