Far-reaching changes in the domestic and global markets are crafting big avenues for farmers and agribusiness entrepreneurs. This study examines the agriculture entrepreneurship and farmers’ performance in the context of the China-Pakistan Economic Corridor (CPEC). A survey was conducted to collect primary data from three agricultural zones adjacent to the under-construction CPEC in Pakistan. According to the results, market orientation, entrepreneurial orientation, innovation orientation, and opportunity recognition positively influence agriculture entrepreneurship thereby facilitating timely distribution of food commodities in ensuring food security. Our findings also indicate that uptake of entrepreneurship complements farmers’ marketing, operational and economic performance. These findings do imply that improving farmers’ entrepreneurial skills is the essential element for their improved performance in terms of locating potential markets and timely delivery of primary commodities, such as food items. It suggests that farmers might seek enormous economic opportunities arising from improved infrastructure, output linkages, connectivity and access to global markets through the CPEC. Based on the findings, the study provides implications for policymakers to channelize the potential endeavors for facilitating the farmers’ access to new markets and getting the foremost advantage of Belt and Road Initiative. The study also extends the existing literature on agriculture entrepreneurship-opportunity recognition and access to new markets in a befitting manner.