The study aims to identify the strengths, weaknesses, opportunities, and threats (SWOT) of renewable energy deployment in regional energy transitions for the regions of Bavaria, Georgia, Québec, São Paulo, Shandong, Upper Austria, and Western Cape, which comprise a political and scientific network called the Regional Leaders’ Summit (RLS) and RLS-Sciences, respectively. The results classify current renewable energy usage for electricity, heat and fuel production, existing renewable energy potentials, sound legal frameworks to support renewable energy, ongoing research and development activities and expertise in renewable energy conversion and storage as strengths. That fossil fuels still hold a significant share in gross inland energy consumption, energy-intensive industrial structures continue to be supported by fossil fuels and grid access is limited for renewables are identified as weaknesses. The main opportunities are green economies, climate change mitigation and technological innovations. Associated threats are demographic developments, lack of social acceptance and renewable energy resource volatility. We conclude that these regions’ energy systems could potentially enable the realization of a strong integration of renewables and cover partially distributed, decentralized energy systems with embedded energy storage, and the application of smart technologies. Furthermore, we discover that the role of governments in guiding and managing regional energy transitions is highly important.