Understanding the impacts of climate variability and change on terrestrial ecosystems in Africa remains a critical issue for ecology as well as for regional and global climate policy making. However, acquiring this knowledge can be useful for future predictions towards improved governance for sustainable development. In this study, we analyzed the spatial–temporal characteristics of vegetation greenness, and identified the possible relationships with climatic factors and vulnerable plant species across Africa. Using a set of robust statistical metrics on the Normalized Difference Vegetation Index (NDVI3g) for precipitation and temperature over 34 years from 1982 to 2015, relevant results were obtained. The findings show that, for NDVI, the annual rate of increase (0.013 y−1) was less than that of decrease (−0.014 y−1). In contrast, climate data showed a sharper increase than a marked decrease. Temperature is increasing while rainfall is decreasing, both at a sharp rate in central Africa. In Africa, tree cover, broadleaved, deciduous, closed to open (>15%) and shrubland plant species are critically endangered. The tropical vegetation devastated by the climate variability, causes different plant species to gradually perish; some were cleared out from the areas which experienced degradation, while others were from that of improvement. This study provides valuable information to African governments in order to improve environmental sustainability and development that will lead to the sustainability of natural resources.