This paper discusses the impact of the COVID-19 pandemic on air pollution. Many urban inhabitants were confined to their homes during the lockdown. This had an impact air pollution, due to a reduction the number of vehicles being operated in cities. People also limited the number of visits to shopping centers; additionally, sports venues were closed and cultural events cancelled. The COVID-19 pandemic therefore had a positive impact on air pollution. Several studies from around the world confirm this. The research presented here is based on hourly measurements of PM10 and NO2 concentrations measured in background ambient air at a specific intersection located in Uherske Hradiste, Czech Republic. The aim of the paper is to confirm or exclude the hypothesis that the measured concentrations of PM10 and NO2 pollutants were lower during 2020 than in 2019, when states of emergency related to the COVID-19 pandemic were declared. The data were aggregated into monthly subsets and statistically analyzed. The data was graphically visualized and evaluated by means of exploratory data analysis. To compare the pollution levels in individual months, a parametric statistical analysis (two-sample t-test) was used. A statistically significant reduction was observed in the measured concentrations in 2020 compared to 2019 during periods when states of emergency were declared.