The performance of solar thermal technology under high-altitude equatorial climatic and solar path conditions has not been determined. Evacuated tube solar collectors are more efficient than flat plate collectors in cold and cloudy regions; however, due to their dependence on orientation, the irradiation incidence between the tubes of these collectors can be blocked. In this study, the performance of these types of collectors was analyzed to determine the implications of their orientation under these specific climate conditions. Four solar thermal systems were installed: two of the systems used evacuated tube collectors, and two used flat plate collectors. Each collector was connected to storage and discharge points to simulate residential consumption when observing the real performance of the four systems in terms of irradiation availability. The evacuated tube collectors were more efficient and reduced the backup energy requirement by up to 20.6% more on average than the flat plate collectors. In addition, the performance of the evacuated tube collectors increased by up to 9.8% when the tubes were arranged parallel to the solar path, compared to when they were arranged perpendicular to the solar path, verifying that the blockage effect is an important parameter to consider for evacuated tube technology. The main novelty of this research is the comparison of these two technologies under different orientations, with perpendicular and parallel dispositions toward the solar path, in a high-altitude equatorial location where solar collectors are not typically oriented in any particular orientation. To the best of our knowledge, this is the first complete analysis of real systems deployed under these conditions.