Context and purpose: This study focuses on identifying the current qualities of enhancing the action of intellectualization of human capital. The main purpose of the article is to identify relevant strategic benchmarks for the intellectualization of human capital in enterprises under conditions of innovative transformation. Research method: The methods of research are synthesis and analysis, used to identify trends in the processes of intellectualization of human capital on enterprises, factor analysis methods in combination with methods of expert evaluations, and other general scientific methods. Findings: The article offers, for the first time, a definition of the essence of intellectualization of human capital as a separate economic process, which is based on the renewal of competencies in accordance with the needs of enterprise development and includes the need for their up-to-date globalization and industry trends in the economy of the country. The relationship between the intellectualization of human capital and innovation has been defined. The influence of factors on the processes of intellectualization of human capital on enterprises in conditions of innovative transformations has been investigated. It was found that such factors are prerequisites for the formation of strategic guidelines for the development of the intellectualization of human capital. The main aspects of innovative transformations by identifying trends of intellectualization of Ukrainian human capital in the international space through the analysis of the Global Innovation Index have been investigated. Conclusion and innovation: Thus, the relationship between the intellectualization of human capital and innovation, which affects the sustainability of economic systems, was determined. According to the results of the study, the key directions of formation and development of strategic guidelines for the intellectualization of human capital of enterprises are proposed.