The supplier selection decision, within the scope of supply chain management (SCM), is one of the key decisions that plays an important role in the success of the business. The supplier selection problem, which aims to determine the most suitable suppliers in line with the demands of the enterprises, can be defined as a Multi-Criteria Decision Making (MCDM) problem that includes both quantitative and non-quantitative criteria. While there is a large body of literature on supplier selection studies using MCDM methods, the number of studies in the health sector is relatively low compared to other sectors. Although much research can be found regarding the application of MCDM techniques in clinical operations, less research has been conducted on the problem of supplier selection in healthcare services, which has a high complexity level. The main purpose of the study is to develop a holistic MCDM model as a decision support system for supplier selection in the health sector. The decision-making trial and evaluation laboratory (DEMATEL) and Analytical Network Process (ANP) methods were used together to analyze the model. The main criteria used in the study are price, quality, logistics, sustainability, and occupational health and safety (OHS). As sustainability and OHS rarely exist in supplier selection studies in the health sector, this holistic model can contribute to the literature in that aspect. According to the findings and the main criteria ranking, the most important criteria, emerged as price, quality, sustainability, OHS, technique, and logistics. The results indicate the importance of sustainability in supplier selection in the health sector. The method proposed in this study may help health managers as a support system for making purchasing decisions.