Land degradation is a permanent global threat that requires an interdisciplinary approach to addressing solutions in a given territory. This study, therefore, analyses environmentally sensitive areas to land degradation using the Mediterranean Desertification and Land Use (MEDALUS) and Geographic Information System (GIS) method through a multi-criteria approach in the district of Florida (Peru). For the method, we considered the main quality indicators such as: Climate Quality Index (CQI), Soil Quality Index (SQI), Vegetation Quality Index (VQI), and Management Quality Index (MQI). There were also identified groups of parameters for each of the quality indicators analyzed. The results showed that 2.96% of the study area is classified as critical; 48.85% of the surface is classified as fragile; 15.48% of the areas are potentially endangered, and 30.46% are not threatened by degradation processes. Furthermore, SQI, VQI, and MQI induced degradation processes in the area. Based on the results, five restoration proposals were made in the study area: (i) organic manure production, (ii) cultivated and improved pastures and livestock improvement, (iii) native forest restoration, (iv) construction of reservoirs in the top hills and (v) uses of new technologies. The findings and proposals can be a basic support and further improved by decision-makers when implemented in situ to mitigate degradation for a sustainable use of the territory.