Globally, the empowerment of women is a critical and challenging issue. In considering the problem, the researchers sought to investigate Women’s Empowerment (WE) in the context of Saudi Arabia. In this study the researchers applied quantitative methods and collected the cross-sectional data through a questionnaire based on a random sampling technique. The study utilized 314 useable samples to conclude the investigation. Using path analysis through Analysis of Moment Structures (AMOS) version 26.0, the study underlines a positive and significant effect of Economic Empowerment (EE) and Social Empowerment (SE) on WE. On the other hand, Political Empowerment (PE) has a negative effect on WE. Moreover, Self-efficacy (SFY) and Family Support (FS) also positively and significantly affect WE. Regarding the mediating effects, SFY mediates the positive relationship of EE and SE with WE. On the contrary, SFY did not develop a positive relationship between PE and WE. Finally, FS plays a crucial mediating role in developing the association between EE, SE, PE and WE among Saudi Arabian women. This study’s findings support policymakers and planners in developing policies and strategies to boost WE significantly. Finally, through the empirical confirmation between EE, SE, PE, SFY, FS and WE in Saudi Arabia, a Middle East country, this study’s findings add further enrichment to the depth of the literature.