Blockchain offers decentralized, trustworthy and immutable data storage based on distributed ledger technology. Blockchain technology is recognized as an innovation enabler in many areas, with the food supply chain being one of them. This paper provides a systematic literature review of the current state of adoption of blockchain technology in the agri-food sector, specifically with a focus on the wine supply chain. Blockchain has the potential to improve the traceability and authenticity of the data provenance of wine products, increase consumer trust, and reduce fraud and errors. With these goals in mind, this study identifies the main research questions pertinent to the value proposition and competitive advantage of blockchain technology in the wine value chain and key players involved in the authentication and value chain recording. The PRISMA methodology was adopted to identify, screen and select only the relevant studies that were included in the analysis. This study also addresses the limitations and challenges for adoption, such as high implementation cost and lack of competences, and the need for standardized protocols and regulations. Finally, this systematic literature review includes an analysis of reports of blockchain applications in the wine sector and outlines the recommendations for future research to further explore the potential of blockchain-based solutions that could benefit all stakeholders across the wine value chain.