Outdoor thermal comfort affects the health of the people and the quality of life in urban areas. This is the reason why in the past few years different mitigation strategies for the microclimate have been studied and examined. These strategies depend on those passive factors characterizing the urban setting that are able to affect the values of local meteorological variables, as the limit surfaces of the urban space (parterre and façades of the buildings). This paper examines the Cloister by Giuliano da Sangallo, which is part of the Faculty of Engineering of Sapienza University of Rome. The case study compares the present configuration of the Cloister with four other configurations characterized by some vegetation and materials with a high albedo by taking into consideration the PMV (Predicted Mean Vote) model. Microclimatic variables are calculated through numerical simulations performed by the ENVI-met software. Such a comparison is performed during a typical summer day. While examining the results it can be noticed how the strategy presenting the best results is the one with some vegetation, whereas the materials with a high albedo improve the microclimate if applied on surfaces characterized by a high sky view factor.