This investigation is related to this study of entropy generation during Carreau nanofluid flow under variable thermal conductivity conditions. The heat and mass transfer phenomena are observed in the presence of thermal radiation and activation energy. The flow is induced by a porous stretching surface. Appropriate variables are used in order to simplify the problem into dimensionless form. The numerical simulations are performed by using the shooting technique. The physical aspects of the problem in view of different flow parameters are reported. It is observed that consideration of variable fluid thermal conductivity enhances heat transfer. An enhancement in heat and mass transfer phenomena is observed with increasing the Weissenberg number. Moreover, entropy generation increases with Weissenberg and Brinkman numbers. Current results present applications in thermal processes, heat exchangers, energy systems, combustion and engine design, chemical processes, refrigeration systems, etc.