Analyzing trends of annual rainfall and assessing the impacts of these trends on the hydrological regime are crucial in the context of climate change and increasing water use. This research investigates the recent trend of hydroclimatic variables in the Senegal River basin based on 36 rain gauge stations and three hydrometric stations not influenced by hydraulic structures. The Man Kendall and Pettitt’s tests were applied for the annual rainfall time series from 1940 to 2013 to detect the shift and the general trend of the annual rainfall. In addition, trends of average annual flow rate (AAFR), maximum daily flow (MADF), and low flow rate (LFR) were evaluated before and after annual rainfall shift. The results show that the first shift is situated on average at 1969 whereas the second one is at 1994. While the first shift is very consistent between stations (between 1966 and 1972), there is a significant dispersion of the second change-point between 1984 and 2002. After the second shift (1994), an increase of annual rainfall is noticed compared to the previous period (1969–1994) which indicates a not significant, partial rainfall recovery at the basin level. The relative changes of hydrologic variables differ based on the variables and the sub-basin. Relative changes before and after first change-point are significantly negative for all variables. The highest relative changes are observed for the AAFR. Considering the periods before and second shifts, the relative changes are mainly significantly positive except for the LFR.