The Nile Delta has been suffering from complex environmental hazards caused by climate change and human-induced evolvements, which have led to adverse impacts on national food security. An unfavourable nexus between solid waste management issues and extreme hydrological events is examined mainly through extensive field investigation and literature research, which is an emerging issue affecting food safety and security whilst still being overlooked so far. The findings not only reveal the significance of the emerging issue but also support our proposed recommendations in the policy/legislation and technology sphere. This interdisciplinary research employs a holistic lens that covers diverse perspectives, including systemic problems, wastewater treatment, and environmental neuroscience, to explore the relationship between food, climate change, water management, and waste pollution, and to achieve novel discoveries for the practical adaptations of Egypt’s challenges.