Maize is a crucial global commodity, which is used not only for food, but also as an alternative crop in biogas production and as a major energy-supply ingredient in animal diets. However, climate change is jeopardizing current maize production due to its direct impact on weather instability and water availability or its indirect effects on regional climate suitability loss. Hence, new areas for sweet maize cultivation should be considered in the future. Therefore, this study focuses on the possibility of producing maize in a challenging environment in Southern Italy considering rainfed cultivation and two irrigation regimes (full and deficit). The experiment was conducted during two subsequent growing seasons under semi-arid Mediterranean climate conditions. The overall results indicated a significant difference in biomass and yield between irrigated and non-irrigated treatments, and between full and deficit irrigation. Sweet maize cultivated under deficit irrigation gained less biomass than under full irrigation and its development and fruit maturation were delayed. Under deficit irrigation, the plants gave lower yields and a higher percentage of the panicle weight consisted of kernels. Irrigation water productivity was higher for deficit than for full irrigated treatment. These findings indicate the feasibility of sweet maize production in semi-arid areas of Southern Italy using adaptive agricultural strategies including deficit irrigation and controlled water stress. Given the importance of maize production, understanding of maize growth and productivity in a challenging environment may support future agricultural programming and thereby contribute e to mitigation of the direct and indirect effects of climate change.